BioNumerics versions

v7.1 [Jun 21, 2013]
- Added spectrum data
- Capillary sequencer data analysis
- Added sequence read sets data type
- Added genome analysis tools module
- Genome maps analysis module
- Classifiers and identification module

v6.6 [Sep 28, 2011]
DATABASE:
- Improved performance of import and database actions on large databases.
ADVANCED CLUSTERING:
- Enabled menu item “Materialize” for MST’s with hypothetical nodes.
- Added a script function for performing the “Materialize” command on an existing network that can be materialized.
- Added a script function to check whether a node is hypothetical.
- Added a script function to retrieve the data from a hypothetical node.
- Solved a bug concerning the enabling of the node label drop-down box.
PRIMER DESIGN:
On starting up the primer design module, the standard zoom modus is now 'full zoom in' (base-level).
- Starting up the primer design module now automatically selects a locus (target for primer design):
- If no selection is defined, the full sequence is taken as target.
- If a feature is selected in the sequence viewer, this feature will be taken as target region.
- If a sequence selection is defined within the sequence viewer or alignment window (discriminative primer design), this selection will be taken as target region. Of course, a locus can be re-edited within the primer design window.
- The button "Add/edit locus" is consequently changed into "Edit locus" and is placed at second position (after "Run"-button).
- Within the primer design settings dialog, two items have been added:
BioNumerics Version 6.6.4 New Features – 2 January 2012. Copyright by Applied Maths NV.
- A checkbox "Write reverse primers in conformance with the minus strand". This means that all reverse primers are written in the reverse-complement direction (with respect to the leading (plus) DNA-strand). This option is by default enabled: all reverse primers will be shown, printed, exported in the reverse-complement orientation. If this option is disabled, reverse primers are written in conformance with the leader (plus) DNA strand.
- Primer settings can now be saved. A priority set can be appointed.
- Within the PCR listing, two buttons have been added for selecting respectively the forward and reverse primer within the view window.
- When primer design is started from a multiple alignment, primers are now displayed with 'base-difference'-indications with respect to the negative selection of sequences. This feature is enabled within sequence viewer, primer listing and PCR listing.
- The export format of primers to the clipboard is now explained by an additional information header (tab-delimited format).
- Title of the locus settings dialog box has changed from "primer target definition" into "Edit locus definition".
- Bug fix: "minimal discrimination".
ALIGNMENT WINDOW:
- A sequence alignment can now be exported from the Alignment window to an open or newly created comparison.